Remarkably, recent studies have shown that p38γ substrates in the CNS include α1-syntrophin, PSD95, MyoD, SAP97, and PTPH1 (Protein-tyrosine phosphatases) (Hasegawa et al., 1999; Sabio et al., 2005; Escos et al., 2016), all of which are synaptic proteins known to be altered in AD and other neurodegenerative disorders (Shao et al., 2011; de Wilde et al., 2016; Bhat et al., 2019). The gene discussed is DLG4; the disease is Alzheimer disease.