MAPT and Alzheimer disease: Aberrant activation of p38α has been extensively studied in AD as an important trigger for amyloid-β-mediated neuroinflammation, tau hyper-phosphorylation, and excitotoxicity (Bachstetter and Van Eldik, 2010; Lloret et al., 2015; Maphis et al., 2016; Lee and Kim, 2017; Kheiri et al., 2018).