RAD21 and trichorhinophalangeal syndrome type II: These two genes could fully explain the disease phenotype with facial dysmorphisms and bone abnormality, which is likely a contiguous gene syndrome, Cornelia de Lange syndrome type IV (CdLs-4) and atypical Langer–Giedion syndrome (LGS), also known as trichorhinophalangeal syndrome type II (TRPSII).