The GRP78 protein expressions in the FO + NEC group at 24 h, 48 h and 72 h of NEC modeling were greater than those in the control group by 14.59%, 29.85, and 27.15, respectively (P < 0.05 for all) and lesser than those in the NEC group by 6.80%, 10.61%, and 8.27%, respectively (P < 0.05 at all 3 time-points). The gene discussed is HSPA5; the disease is necrotizing enterocolitis.