MITF and melanoma: Relatively low levels of variability were observed in expression of genes linked to melanoma cell phenotype (i.e., melanocytic, MITF-related, and AXL-related gene sets); however, the same samples that displayed prominent and uniform immune signature upregulation also displayed a non-melanocytic phenotype that is known to be associated with mesenchymal-like and pro-invasive cellular behaviors, evidenced by high expression of the AXL-related gene set, and correspondingly low expression of the melanocytic and MITF-related gene sets (Supplementary Fig. 3A)17,18.