Meanwhile, we observed that the CREKA-functionalized micelle resulted in low degree fibronectin expression alongside low-level CD31 and Ki-67 expression, while high-level expression of fibronectin was observed in DOX and D + V treated groups, implying the metastatic sites contained highly invasive tumor cells rather than the low invasive potential of metastatic site tumor cells in the C-DVM group. This evidence concerns the gene MKI67 and neoplasm.