FN1 and cancer: These tumor cells release large quantities of chemokines and proteins to attract immune cells and stimulate angiogenesis, thus promoting the development of a unique inflammatory and highly vascularized niche.18 Cancer-associated fibroblasts have also been shown to drive and direct cancer cell migration through fibronectin alignment.19 In addition, hypoxia,20 metabolic stressors, and matrix stiffness21 trigger the EMT program in cancer cells.