DCX and neoplasm: Neural progenitors from the central nervous system that express doublecortin infiltrate prostate tumors and metastases.167 These progenitors initiate neurogenesis, which is the process by which neurons are produced from neural stem cells.168 These nerve fibers in the tumor microenvironment regulate cancer initiation and dissemination, providing insights into how doublecortin-expressing neurons can be targeted for therapy.