In addition, upon the eradication of neutrophils in mice with breast tumors, the number of CTC–neutrophil clusters was markedly decreased.201 These mice had delayed metastases in the lungs when compared with those of mice bearing breast tumors that did not have their neutrophils depleted.201 Moreover, the complex interchange between cancer cells and white blood cells facilitates metastasis, because metastatic cells possess sugar on their cell surface that binds to galectin-3.202 This enhances the ability of cells to colonize by interacting with mobilized white blood cells.202. The gene discussed is LGALS3; the disease is breast neoplasm.