The activated B cell-like subtype of DLBCL (ABC-DLBCL) is characterized by antigen-driven BCR signaling,173,174 while germinal center B cell-like (GCB)-DLBCL features tonic, antigen-independent BCR signaling.175,176 BL is also characterized by tonic BCR signaling and mostly relies on SYK.177 In T-NHLs, aberrant SYK expression was reported in monomorphic epitheliotropic intestinal T-cell lymphomas (MEITL, type II EATL),178 the follicular variant of PTCL, not otherwise specified (PTCL-NOS), and angioimmunoblastic T-cell lymphoma (AITL) due to t(5;9)(q33;q22) ITK/SYK translocation.179–181. Here, ITK is linked to diffuse large B-cell lymphoma.