CD40 and neoplasm: CD40 is expressed on B cells, monocytes, dendritic cells, endothelial cells and epithelial cells and plays a critical role in the regulation of immune responses.150 In addition, CD40 is expressed on B-NHLs, leading to the modulation of tumor cell growth after binding with its natural ligand (CD40L).151 Dacetuzumab (SGN-40) is a humanized IgG1 mAb targeting CD40.