BCR and diffuse large B-cell lymphoma: mTORC1 phosphorylates 4E-BP1 and S6K1 to activate key drivers of protein translation (Fig. 1).212 Downstream signaling of BCR is largely dependent on p110δ, and mutations in PIK3CA (the gene encoding p110α) were found in approximately 1–8% of DLBCL.213,214 In T-NHLs, p110δ and p110γ are vital kinases of TCR signaling and chemokine receptor signaling, respectively.215–217