ALK and mature T-cell and NK-cell non-Hodgkin lymphoma: In T-NHLs, BCL-6 is detectable in some types of PTCL, especially ALK+ ALCL and lymphomas derived from TFH cells, particularly AITL.481,482 Oncogene addiction is switched to BCL-2 and BCL-XL in the context of BCL-6 inhibition.483 To solve this problem, a combined treatment of RI-BPI (a BCL-6 inhibitor) and ABT-737 might be a choice but needs more experimental verification.