Once GC B-cells begin their differentiation into memory B-cells and PCs with an appropriate affinity for the inciting antigen, BCL-6 will be phosphorylated and subsequently degraded by the proteasome.476 Moreover, BCL-6 regulates TFH cell differentiation.477,478BCL-6 translocations are found in 40% of DLBCL, 48% of nodular lymphocyte-predominant Hodgkin lymphoma, and 5-10% of FL.445,479,480 ABC-DLBCL patients have more BCL6 translocations than GCB-DLBCL patients (24% vs. 10%). The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.