Mutations of EP300 were observed in 10% of DLBCL.329 In PTCL-NOS, CREBBP and EP300 are mutated in 4% and 8% of patients, respectively.328 In NKTCL, EP300 is mutated in approximately 3.8% of patients.243. The gene discussed is CREBBP; the disease is diffuse large B-cell lymphoma.