MYC and lymphoma: They encode the related transcription factors MYC, MYCN, and MYCL, also known as c-MYC, N-MYC, and L-MYC, respectively.444 The Ig-MYC translocation is the most common type of MYC alteration and can cause MYC overexpression.445 MYC is expressed at the pro-B and pre-B-cell stages and in a minority of GC B-cells.446–448 Additionally, MYC is frequently overexpressed in lymphomas of GC origin.