MYC and diffuse large B-cell lymphoma: In BL, the t(8;14) translocation is found in approximately 80% of all patients.449 In DLBCL, MYC overexpression is shown in 30–50% of patients.450,451MYC translocations preferentially occur in GCB-DLBCL over ABC-DLBCL (17.7% vs. 6.7%).450 A high level of MYC is associated with a low treatment response and poor prognosis in DLBCL patients treated with R-CHOP and may also lead to an increased relapse rate in the central nervous system.452,453