CD274 and Hodgkins lymphoma: Treatment with kaempferol led to lower body weight loss and higher survival than the control treatment.138 In Hodgkin lymphoma, PIM kinases have been shown to contribute to the immunosuppressive environment through modulation of PD-L1/2 (programmed death-ligand) activity, and although the PIMs are not key drivers of this phenotype, there is some rationale to support investigating the co-targeting of the PIM family (via the pan-PIM inhibitor SEL24) with PDL-1 (139).