NKX3-1 and posterior cortical atrophy: Coexpression of PIM and MYC has been shown to result in increased proliferation and apoptosis, the latter possibly due to increased cell turnover.37 Moreover, PIM and MYC coexpression can be correlated with a higher Gleason grade of PCa.37 MYC promotes prostate tumorigenesis by affecting ribosomal DNA and RNA, activation of pro-tumorigenic genes such as EZH2 (enhancer of zeste homolog 2) and downregulation of tumor suppressor genes such as NKX3.1 (homeobox protein Nkx-3.1).97