Further studies demonstrated that WIP1 indeed induced stemless-related proteins and CSC properties by inhibiting p38 in NSCLC cells in vitro and in vivo, and that the WIP1 inhibitor GSK283071 activated p38 and suppressed stemness-related protein expression and CSC properties in a p38-dependent manner in NSCLC cells. This evidence concerns the gene PPM1D and non-small cell lung carcinoma.