In a recent paper published in Nature, Gate et al. reported adaptive immune changes in Alzheimer’s disease (AD), discovered CD8+ T effector memory CD45RA+ (TEMRA) cells with proinflammatory and cytotoxic functions in AD patients, and identified two TEMRA cell-recognized antigens of human herpesvirus 4 (HHV-4), also known as Epstein–Barr virus (EBV).1 The findings suggested that adaptive immunity might have a role in AD progression. The gene discussed is CD8A; the disease is Alzheimer disease.