NFKB1 and colorectal cancer: TNFRSF19, a member of the TNF receptor superfamily, is regulated in a β-catenin-dependent manner, but its receptor molecules activate NF-κB signaling to regulate the development of colorectal cancer.400 Knockdown of CD146 results in inhibition of NF-κB/p65-initiated GSK3β expression, which promotes nuclear translocation and activation of β-catenin.401 In addition, there is negative regulation between Wnt/β-catenin and NF-κB signaling.