JAK2 and central nervous system cancer: For example, miR-500a-3p targets multiple negative regulators of the JAK2/STAT3 signaling pathway, such as SOCS2, SOCS4, and PTPN, in HCC stem cells, leading to constitutive activation of STAT3 signaling.322 MiR-30 targets SOCS3 in glioma stem cells.337 Mir-93 downregulates the expression of JAK1 and STAT3 to induce the differentiation of breast CSCs.