MYC and cancer: The overexpression of MYC in normal human cells may be ineffective or highly destructive, resulting in stagnation of proliferation, aging, or apoptosis.110 MYC is usually deregulated in human cancers, plays an important role in maintaining the number of invasive CSCs,111 and is also one of the most effective oncogenes for detecting the cell transformation phenotype in vitro and in vivo.