Disulfiram, an anti-alcoholism drug, inhibits tumor growth factor-β (TGF-β)-induced metastasis via the ERK/NF-κB/Snail pathway in breast CSCs.301 Sulforaphane preferentially inhibits self-renewal in triple-negative breast CSCs by inhibiting NF-κB p65 subunit translocation and downregulating p52 and its transcriptional activity.302 Curcumin regulates the proliferation, metastasis, and apoptosis of HCC stem cells by inhibiting the NF-κB pathway.303 These data demonstrate that amplified NF-κB signaling is important for regulating apoptosis, proliferation, and metastasis of CSCs. The gene discussed is NFKB1; the disease is alcohol dependence.