Increased expression of FOXP3 has been identified in different cancers.298 FOXP3 interacts with NF-κB, inhibits the expression of COX2 located downstream of NF-κB, and affects self-renewal and metastasis in colorectal CSCs.299 Overexpression of miR-491 blocks the activation of NF-κB in liver CSCs by targeting G protein-coupled receptor kinase-interacting protein 1, which inhibits ERKs.300 Moreover, some drugs inhibit cell proliferation and metastasis of CSCs by the NF-κB pathway. The gene discussed is NFKB1; the disease is cancer.