This condition is very common in basal cell carcinoma, rhabdomyosarcoma, and medulloblastoma.232,233 Other Hh pathway components are also mutated in human cancers, such as Gli1 and Gli3 mutations in pancreatic adenocarcinoma, Gli1 gene amplification in glioblastoma, and SUFU (suppressor of fused) mutations in medulloblastoma.234,235 In addition, other genes also regulate the Hh signaling pathway. The gene discussed is GLI1; the disease is cancer.