Vismodegib even has better activity in patients with recurrent Shh-mb but not in patients with recurrent non-Shh-mb.604,605 Vismodegib has also been tested in metastatic colorectal cancer,606 pancreatic cancer,607 chondrosarcoma,608 relapsed/refractory NHL, CLL,609 and ovarian cancer.610 Disappointingly, these treatments with vismodegib have not resulted in better survival. Here, SHH is linked to ovarian cancer.