However, deletion of PTEN in neural stem cells leads to a neoplastic phenotype that includes cell growth promotion, resistance to cell apoptosis, and increased migratory and invasive properties in vivo.359 Inactivation of PTEN and activation of protein kinase B have been found in other solid tumors, such as myeloproliferative neoplasia and leukemia.360 Therefore, the PI3K/mTOR signaling pathway is vital for cell proliferation and survival. This evidence concerns the gene PTEN and leukemia.