SOX2 and osteosarcoma: Furthermore, osteosarcoma cells that lose Sox2 cannot form osteospheres and differentiate into mature osteoblasts any longer.84 Sox2 is found in invasive cutaneous squamous cell carcinoma (SCC) and promotes the metastasis of cancer cells.85 These studies suggest that Sox2 promotes self-renewal and tumorigenesis and inhibits differentiation in CSCs.