SMO and plasma cell myeloma: For example, miR-324-5p significantly decreases SMO and Gli1 in myeloma stem cells.270 Mir-326 directly downregulates SMO and Gli2 in medulloblastoma stem cells.271 MiR-326 downregulates SMO in glioma stem cells.272 Mir-122 targets Shh and Gli1 in lung CSCs.273 These data demonstrate that amplified Hh signaling is important for the self-renewal, growth, and metastasis of CSCs.