For example, ectopic USP51 correlates with a shorter overall survival rate and poorer outcomes in breast and colon cancer patients.33 Here, our study expanded on the multifaceted role of USP51 in cancer progression by demonstrating its function as a key metastasis activator through the promotion of ZEB1-mediated EMT, migration and metastasis. The gene discussed is ZEB1; the disease is colonic neoplasm.