FOLR2 and central nervous system cancer: A significantly depleted TAMs and reduced tumor growth in an experimental glioma model.21 Depletion of TAMs by zoledronic acid entrapped in folate-linked liposomes can selectively induce in vitro cytotoxicity via FRs.22 All these results reveal that FRβ is an attractive target for TAM-selective delivery, but no FRβ-associated targeted therapy for lung cancer TAMs has been reported.