We found that high FRβ expression was an independent predictor of lung adenocarcinoma prognosis (p = 0.003, 95% CI 1.491–6.536) and an independent predictor of lung squamous cell carcinoma prognosis (p = 0.002, 95% CI 1.793–12.465). This evidence concerns the gene FOLR2 and lung adenocarcinoma.