FOLR1 and neoplasm: Stromal TAMs are associated with poor prognosis in non-small cell lung cancer.35,36 Some studies seek to find reliable targets in TAMs, but currently, such targets are rare.37 The FR, a high-affinity membrane folate-binding protein, has been found to be overexpressed in various tumors.38–43 The efficacy of folate liposomal complexes in tumor-specific targeted therapies has been demonstrated.28,32,44 However, most research is limited to tumor types with high FRα expression in tumor cells.