The transcription factor c-Jun is a downstream driver of the Wnt/β-catenin signaling pathway.34 Interestingly, we further determined that c-Jun transcriptionally activated MYH9 and ubiquitin expression to participate in MYH9-mediated ubiquitination and degradation of GSK3β, thus forming the positive regulatory loop MYH9/GSK3β/β-catenin/c-Jun in HCC progression. This evidence concerns the gene GSK3B and hepatocellular carcinoma.