It can target USP2 and USP7 and trigger apoptotic cell death in cancer cell lines (Fig. 5).432 Pimozide, a specific USP1 inhibitor, can block glioma stem cell maintenance and radioresistance (Table 1).435 WP1130, a small-molecule compound, also inhibits the activity of several DUBs, including USP9x, USP5, USP14, UCHL5 and UCH37. This evidence concerns the gene UCHL5 and glioma.