The natural compound oridonin promotes FBW7-mediated proteasomal degradation of c-Myc, thereby inducing apoptosis in leukemia and lymphoma cells.398 By small molecule screening, SCF-12 allosterically inhibits the recognition of the substrate FBP Cdc4 (a homolog of FBW7 in yeast) but not its human ortholog FBXW7 (Table 1).399. This evidence concerns the gene FBXW7 and leukemia.