The natural compound oridonin promotes FBW7-mediated proteasomal degradation of c-Myc, thereby inducing apoptosis in leukemia and lymphoma cells.398 By small molecule screening, SCF-12 allosterically inhibits the recognition of the substrate FBP Cdc4 (a homolog of FBW7 in yeast) but not its human ortholog FBXW7 (Table 1).399. Here, FBXW7 is linked to lymphoma.