N-4-Tosyl-l-arginine methyl ester (TAME) binds to the APC E3 ligase and inhibits its activation by targeting both CDH1 and CDC20 and inducing mitotic arrest.408 Another small molecule called apcin (APC inhibitor) binds directly to CDC20, competitively inhibits the ubiquitination of D-box-containing substrates, blocks mitotic exit, and then induces tumor cell death (Table 1).409. This evidence concerns the gene APC and neoplasm.