PTEN and progressive multifocal leukoencephalopathy: USP7, a highly expressed DUB in prostate cancer and progressive multifocal leukoencephalopathy (PML), plays a direct role in PTEN deubiquitination and regulates its localization rather than protein stability.170 In addition, USP13 and OTUD3 can interact with PTEN and remove its polyubiquitin chain.