Structurally, they are mimics of p53 and specifically bind to the pocket on Mdm2, thereby disrupting the protein–protein interface.379 Nutlins have been shown to inhibit the growth of hematological malignancies, glioblastomas and AML cells by activating the p53-dependent apoptotic pathway.378,380,381 In addition, they do not induce apoptosis in normal cells.382 Although the primary results of nutlins are promising, their shortcomings have recently been uncovered. The gene discussed is TP53; the disease is glioblastoma.