Infusion of IGF-1 improves hemodynamic parameters, such as renal plasma flow (RPF), inulin clearances (GFR), and renal vascular resistance (RVR), in fasted rats.77 Previous studies have shown that IGF signaling is highly involved in kidney development and different types of kidney diseases, including AKI.78,79 However, the function of IGF in AKI is still controversial. The gene discussed is IGF1; the disease is kidney disorder.