FGF21 and acute kidney injury: FGF-21 knockdown accelerates cisplatin-induced tubular cell injury via p53-dependent mechanisms, but this effect is attenuated by supplementation with recombinant FGF-21.58 Additionally, a study showed that bFGFR2 knockdown prevented the repair process and induced a fibrotic response after ischemic injury, indicating the therapeutic potential of bFGFR2 in AKI.59