EGFR and colorectal carcinoma: Bile acids are among the major microbial metabolic products, which are also relevant to the initiation and progression of CRC.473 The crosstalk between the gut microbiota and the host intestinal cells is considered to be mediated by the progression of primary-secondary bile acid transformation, which mainly regulates the growth of colon epithelial cells via EGFR and nuclear farnesoid X receptor signaling.474 Thus, more investigation is needed to confirm that microbial interventions, such as the use of probiotics, could reduce intestinal inflammation through EGFR regulation.