AKT1 and diabetes mellitus: Cancer and diabetes are closely related to poorly regulated AKT activity.58,59 AKT regulates cell cycle entry and survival via phosphorylation of forkhead box O, BCL2-associated agonist of cell death, and glycogen synthase kinase 3 (GSK-3), thereby preventing cellular apoptosis through mammalian target of rapamycin activation.57–59