EGFR and colorectal carcinoma: For second-line treatment of CRC or beyond, anti-EGFR agents might be low priority because in several studies cetuximab and panitumumab have been demonstrated to fail to reach statistically better PFS or OS for patients with CRC.94–96 In fact, only one study97 reported that panitumumab significantly prolonged PFS (8 vs. 7.3 weeks, HR = 0.54, p < 0.001) compared with best supportive care in patients with chemorefractory CRC with an acceptable rate of adverse events.