The same increase in the RNA expression of MAML3, PSEN2, and Hes1, as well as the Notch downstream target genes Hes5, Hey1, Deltex1, and RBPJ, was observed upon treatment with AC220 of two human FLT3/ITD+ AML cell lines (MOLM13 and MV4-11) (Fig. 1b, c). This evidence concerns the gene HES5 and acute myeloid leukemia.