Moreover, in two independent datasets, GSE2954423 and GSE61715,24 the expression of CXCR3 was downregulated by a 3-day GSI treatment in the acute lymphocytic leukemia cell line CUTLL1 and upregulated in midostaurin-resistant MV4-11 cells (Fig. 4f, g). The gene discussed is CXCR3; the disease is acute lymphoblastic leukemia.