JAK2 and diffuse large B-cell lymphoma: Both the tyrosine kinase JAK and the cytosolic transcription factor STAT are composed of several subunits, and activation of JAK and STAT proteins through the phosphorylation of specific tyrosine residues is closely associated with tumor progression.21,22 In the current study, the decreased levels of p-JAK2 and p-STAT3 following treatment with DCZ0858 provided insights into the antitumor effects of this novel agent in DLBCL cells.