BRAF and cancer: This approach appeared to be a highly sensitive detection method when used to detect two cancer mutants, BRAF V600E and EGFR L858R.57 Another system called DETECTR (DNA endonuclease-targeted CRISPR trans-reporter) has also been developed.261 Cas12a acts like Cas13a in this system, and another enzyme, recombinase polymerase amplification (RPA), is used as a detection tool to screen for viral infections in cancer and to amplify microsamples.