Accordingly, when we compared the cell cycle profiles of primary LECs and the cancer-derived iSLK.219 cells after EMI1 depletion, we found rereplication occurring only in iSLK.219 cells (about 45% of the cells were >G2 at 48 h after EMI1 depletion), while most of the LECs remained in G1 with less than 1% of EMI1-depleted LECs undergoing rereplication (Fig. 5A). Here, FBXO5 is linked to cancer.