FBXO5 and cancer: Next, upon EMI1, CDH1, and CDC20 depletion in iSLK.219 cells, we observed a 3-fold increase in the number of 5-ethynyl-2’-deoxyuridine (EdU)-positive cells (i.e., cells going/gone through S-phase) (Fig. 3G), suggesting a profound alteration of cell cycle regulation, as already reported for other cancer-derived cell lines (19, 44).