AP2A1 and Alzheimer disease: AP2A1, subunit of the adapter protein 2, participates as an interacting partner with ADAM10 for removal of ADAM10 from the plasma membrane (47), suggesting that changes in ADAM10 localization may affect its α-secretase function to limit amyloid-beta (Aβ) formation (48); moreover, AP2/ADAM10 association is increased in AD patients (47).