The repeat domain of Tau with the LM mutations P301L and V337M (Tau-RD-LM) of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) (27, –29) was expressed in human iPSC neurons and resulted in prominent accumulation of intracellular NFTs (18). The gene discussed is MAPT; the disease is frontotemporal dementia.