Targeting Cdc7 through siRNA knockdown in cancer cells has been shown to result in cancer cell-specific apoptotic cell death (Bonte et al. 2008; Kulkarni et al. 2009; Hou et al. 2012), whereas non-cancerous cells arrest in G1 and resume proliferation after Cdc7 activity is restored (Rodriguez-Acebes et al. 2010). The gene discussed is CDC7; the disease is cancer.