CXCR4 and acute myeloid leukemia: We explain the potent antineoplastic effect obtained in the bone marrow, circulating cells, and extramedullar sites without associated toxicity, in our model, by the achievement of a high selectivity by the T22-GFP-H6-Auristatin NC in CXCR4+ AML cell killing, and the consequent elimination of leukemic stem cells (LSCs).