Nonetheless, Wang et al. [39] reported that one unique mutational signature in Chinese patients with NSCLC is associated with an increasing EGFR mutation rate together with gene fusions, such as RET and ALK. In one retrospective analysis, concurrent EGFR mutations were found in 7 of 47 RET-rearranged adenocarcinomas [3]. This evidence concerns the gene ALK and adenocarcinoma.