IFNL3 and hepatitis C virus infection: Several polymorphisms near the type III interferon lambda (IFNL3) locus, previously named interleukin 28B (IL28B), are able to predict both spontaneous clearance of hepatitis C infection by the host as well as better responses to pegylated interferon-alpha/ribavirin (PEG/RBV) therapy for HCV infection [14–17].