IFNL4 and HIV-1 infection: Taken together with previous literature [9, 30], these data are consistent with an overall more favourable immunological profile in the setting of long-term treated HIV-1 infection in those with the rs368234815 [ΔG/ΔG] genotype; the presence of which is linked with both enhanced IFNL4 activity and Th1 responses [31–33].