Since SNPs in this IFNL3/4 region have been extensively related to HCV infection outcomes, including treatment-induced and spontaneous viral clearance, associations between CD4+ and CD8+ T-cell sub-populations with IFNL SNPs were further investigated in a subgroup of virally suppressed PLWH without HCV coinfection (n = 71). The gene discussed is CD4; the disease is coinfection.