Presence of the minor allele rs368234815 (ΔG) has been associated with poorer immune responses to CMV infection and higher risk of CMV retinitis in a cohort with advanced HIV-1 infection (nadir CD4+ T-cell counts of < 100 cells /mm3) [23], while rs368234815 (ΔG/ΔG) homozygous individuals undergoing solid organ transplant from CMV seropositive donors had a significantly higher cumulative incidence of CMV reactivation [24]. Here, CD4 is linked to HIV-1 infection.