For instance, UHRF1 drives HCC through inducing global DNA hypomethylation, and further study revealed that lncRNA UPAT can directly bind to UHRF1 and therefore protect it from degradation, indicating that lncRNA UPAT-mediated UHRF1 stabilization may be an oncogenic factor of HCC [88, 89]. The gene discussed is UHRF1; the disease is hepatocellular carcinoma.