CDK4 and hepatocellular carcinoma: As to the cell cycle regulated by lncRNAs and its roles in HCC proliferation, Cao et al. reported that lncRNA UFC1 binds to mRNA stabilizing protein HuR to upregulate the expression of β-catenin and a series of checkpoint proteins including CDK4/6, c-Myc and cyclin D1, leading to G1/S phase transition and enhanced proliferation of HCC cell [54].