The major findings of the current study were as follows: (1) RDN aggravated endothelial endocrine dysfunction and intimal thickening of renal arteries; (2) RDN significantly increased the renal arterial level of oxidative stress; and (3) RDN significantly activated the nuclear translocation of NF-κB and increased the risk of atherosclerosis of renal arteries. This evidence concerns the gene NFKB1 and atherosclerosis.