IGFBP2 and Familial prostate cancer: PSA can cleave a number of proteins, such as the insulin-like growth factor binding protein (IGFBP2,3,5), Parathyroid hormone-related protein (PTH-related protein), latent TGF-β2, fibronectin and laminin (extracellular matrix components) Whose destruction is the first step in tumorigenesis, metastasis and development of prostate cancer [44–46].