LGALS3 and heart failure: Accordingly, galectin-3 can mediate production of profibrotic factors and collagen accumulation in a variety of diseases.11 Indeed, galectin-3 expression is abnormally increased in fibrotic patients18–21 while galectin-3 inhibition can attenuate cardiac fibrosis in rat and mouse models of heart failure.22 In the present study, we investigated the role of galectin-3 in regulating macrophage invasion and consequent modulation of atherosclerotic plaque phenotype.