PARP1 and neoplasm: As NQO1 is typically overexpressed in tumors but not at a significant level in normal healthy cells [109], the application of NQO1-bioactivatable agents is an attractive possibility for tumor-selective generation of H2O2-induced DNA damages that hyperactivate PARP and deplete NAD+ to cause eventual cell death, which is vital for developing safe and effective drugs with minimal off-target effects.