The incidence of DME after 10 years of diabetes is 20.1% in type 1 diabetics, 25.4% in type 2 diabetics requiring insulin, and 13.9% in type 2 diabetics not requiring insulin, as reported by the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) [57]. The gene discussed is INS; the disease is diabetic retinopathy.