In agreement with the haemorrhagic lesions and levels of viral replication found in foetuses infected with the high virulence CSFV Margarita strain, it is likely that the increase of IFN-γ and sCD163 may be associated with the exacerbated immune response in the host after infection, leading to cellular homeostasis imbalance and tissue damage. The gene discussed is IFNG; the disease is infection.