CDK4 and neoplasm: For the mechanism of cell cycle, apoptosis, and tumor prognosis, we found that G1 phase drivers decreased after CC12 treatment in U87MG cells, including cyclinD1, CDK2, and CDK4; apoptotic proteins γ-H2AX, Bid, Bax, caspase 3,8 and 9, PARP, P53, and ATR increased, and the anti-apoptotic protein Bcl2 decreased in U118MG and U87MG cells after CC12 treatment.