In the same way, Mansor et al. have found using an agarose drop migration assay that CXCL12 released from PLGA NPs (PLGA-COOH proportion (0%) allowing 75% CXCL12 encapsulation efficiency) can promote the migration of U87 MG GBM cells transfected to express CXCR4 receptors [26]. The gene discussed is CXCL12; the disease is glioblastoma.