Finally, promoter hypermethylation of the cyclin-dependent kinase Inhibitor 2A (CDKN2A) gene, which acts as tumor-suppressor by regulating cell cycles through encoding the p16INK4a and p14ARF proteins, has also been reported in HGOS and suggested to be correlated with metastasis development [30]. The gene discussed is CDKN2A; the disease is neoplasm.