Moreover, limited evidence are available for baraticinib, a numb-associated kinase (NAK) inhibitor, with a particularly high affinity for the kinase AAK1, a pivotal regulator of clathrin-mediated endocytosis, anakinra, an anti IL-1, used in some UTI settings in Lombardy, Italy, and faviparavir a RNA-dependent RNA-polymerase inhibitor. The gene discussed is TBK1; the disease is bacterial urinary tract infection.