A study published in 2016, described a regulatory effect of MYCN on the expression of MTHFR, repressing it [32], and some time before, in ANR (Advances in Neuroblastoma Research Association) meeting 2014, an abstract by N. Svergun et al. [33] concluded that this SNP was related to NB susceptibility and MYCN amplification. This evidence concerns the gene MYCN and neuroblastoma.