In this regard, Prof. Pingarrón’s research group has demonstrated the potential of electrochemical biosensors in the simultaneous determination of two CRC-associated biomarkers in a single run, i.e., the interleukin-13 receptor α2 (IL-13Rα2) and cadherin (E-CDH or CDH-17), which are of relevance in metastasis processes. The gene discussed is CDH17; the disease is colorectal carcinoma.