CD38 and paracoccidioidomycosis: Moreover, DARA has been detected in circulation 70 to 100 days post-infusion, causing interference long after the drug has been stopped (3). In our study, we demonstrate the use of biotinylated recombinant CD38, which is the specific ligand for the DARA antibody, and its efficiency in removing the drug spiked in normal patient sera as well as endogenous residual circulatory DARA in sera from PCM patients.