The results of immunohistochemistry showed that the inflammatory cytokines IL-1β, TNF-α, and TLR4/MyD88-NF-κB signaling pathway-related factors in the hippocampus CA1 and CA3 regions of MG mice were significantly increased in expression levels compared with CG (p < 0.01). The gene discussed is TLR4; the disease is myasthenia gravis.