Notably, an EVO diet supplemented with EVO-extracted polyphenols has more pronounced protective effects than an EVO diet alone in a murine DSS-induced chronic colitis model, as shown by the downregulation of inflammatory genes, such as tumor necrosis factor α (TNFα) and monocyte chemoattractant protein 1 (MCP1) [35]. The gene discussed is CCL2; the disease is Chronic colitis.