Considering the increased AIM2 expression in the small intestine at 7 days after the STZ injection and the increased proinflammatory response in the PLNs of the AIM2−/− diabetic mice, we hypothesized that AIM2 controls gut microbiota translocation to PLNs during T1D and prevents the development of a proinflammatory response against insulin-producing β cells. This evidence concerns the gene INS and type 1 diabetes mellitus.