Surprisingly, the AIM2−/− mice were more susceptible to STZ-induced T1D, when compared to the WT mice, since 100% of the former developed the disease earlier, at day 7 after STZ induction, and, as expected, neither the WT nor the AIM2−/− mice became diabetic after the vehicle injection (Figure 2A). This evidence concerns the gene AIM2 and type 1 diabetes mellitus.