Co-infection studies using cell-fusing agent virus (CFAV, Flavivirus) and dengue virus (DENV) in Aag2 cells shows mutual interaction through activation of Ribonuclease K (AeRNASEK) expression [14], whereas in Ae. aegypti mosquitoes, CFAV negatively interfered with DENV-1 and ZIKV infection [15]. This evidence concerns the gene RNASEK and Zika virus infectious disease.