Moreover, bile acid disbalance seems to be relevant to metabolic regulation as bile acids modulate Glucagon-like Peptide 1 (GLP1) synthesis and secretion, which modulates food intake, intestinal motility, and insulin secretion and thus impacts obesity and T2D pathogenesis [83] as well as intestinal integrity [84]. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.