Recent metabolic studies showed that Lyso-Gb-3 analogs (Lyso-Gb-3(−28), Lyso-Gb-3(−2), Lyso-Gb-3(+16), Lyso-Gb-3(+18), Lyso-Gb-3(+34), Lyso-Gb-3(+50)) are higher in GLA knockout mice and also present in plasma and urine samples in FD patients with the highest Lyso-Gb-3 levels [63,64,65]. Here, GLA is linked to Fabry disease.