The intersection between cancer-associated and circadian genes in both cell lines resulted in three genes, SIRT1, AKT1, and mTOR. SIRT1 is a well-characterized circadian regulated member of Sirtuins family involved in histone and/or protein deacetylation [74], and plays an important role in various cancer related processes such as inhibition of apoptosis for cell survival and oxidative damage or DNA damage induced senescence. The gene discussed is SIRT1; the disease is cancer.