BMAL1 and cancer: The top candidate genes with the highest frequency of mutations (cut-off of 4%) were depicted in Figure 6A. Among the most frequently mutated candidates we found genes known to be associated with cancer (TP53, PIK3CA, and ATM), core-clock genes (PER1, PER3, and ARNTL), and elements of the ECCN (CREBBP and EP300) (Figure 6A).