MTOR and cancer: The intersection between cancer-associated and circadian genes in both cell lines resulted in three genes, SIRT1, AKT1, and mTOR. SIRT1 is a well-characterized circadian regulated member of Sirtuins family involved in histone and/or protein deacetylation [74], and plays an important role in various cancer related processes such as inhibition of apoptosis for cell survival and oxidative damage or DNA damage induced senescence.