In SW620 cells, we found six genes to be circadian expressed (AKT1, MTOR, SIRT1, PPARG, SOD2, TP53) among the cancer hallmarks-associated set, and three of the genes (AKT1, MTOR, and SIRT1) were also oscillating in SW480 cells (Figure 5B). The gene discussed is SIRT1; the disease is cancer.