AKT1 and cancer: These candidate genes were HSPH1, HTT, SIN3A, and CLTC. Alterations in expression of our candidate genes showed correlation with patient survival in core clock components PER3, NR1D1, and CSNK2A1 and angiogenesis related VEGFA. Furthermore, our analysis highlights the link between the core-clock genes to cancer hallmark genes such as AKT1, MTOR, and MYC based on the literature.