The intersection of differentially expressed genes (DEG) and our list of candidate genes, resulted in 12 elements including cancer associated genes (NRAS, MYC, and VEGFA), circadian drug targets (SOD2 and CES2) and core-clock and ECCN genes (AHR, CREB1, CSNK2A1, NFIL, NPAS2, NR1D1, and PER3) (Table S5). The gene discussed is CES2; the disease is cancer.