Immunohistochemical analysis for EPHB3 expression was conducted with normal small (n = 1) and large (n = 5) intestine, and various precancerous lesions including hyperplastic polyps (HPs, n = 5), sessile serrated adenomas (SSAs, n = 5), traditional serrated adenomas (TSAs, n = 3), and conventional tubular adenomas with low grade dysplasia (TAs, n = 5). Here, EPHB3 is linked to tubular adenoma.