Furthermore, their results showed that NEK2 knockdown inhibited CSC-like properties in HCC, including self-renewal, chemotherapeutic resistance properties, and downregulation of the expression of stemness associated-genes of CSCs, such as Nanog, Sox2, Bmi-1, EpCAM, CD133, K19, LIN28, and NOTCH1 [89]. The gene discussed is NEK2; the disease is hepatocellular carcinoma.