Inflammation in adipose tissue, i.e., “adiposopathy”, has been regarded as the main pathogenic pathway that leads to insulin resistance in peripheral tissues and subsequent development of T2D; it is characterized by infiltration of macrophages in adipose depots and is attributed to epidermal growth factor receptor (EGFR)-mediated chemotaxis and proliferation of monocytes and macrophages. The gene discussed is EGFR; the disease is Insulin resistance.