A total of 16 common DEGs across all the three tissues were found to be associated with the HOMA-βtrait in our T2D-interactome (CDKAL1, ACVRL1, APOE, SYVN1, SPP1, SCARB1, CNDP2, DNMT1, SRC, TRIB3, EGFR, MAPK14, ATP2A2, IGFBP5, D1, and PRKAA1). Interestingly, 13 of these genes already have been reported in diabetes or its related phenotypes in the DisGeNET database [16] and therefore validated our network-based bioinformatics approach (Figure 1). The gene discussed is SPP1; the disease is type 2 diabetes mellitus.